Access to the Published Version May Require Journal Subscription. Published with Permission From: Blackwell Synergy

نویسندگان

  • Daniel Agardh
  • Kristian Lynch
  • Charlotte Brundin
چکیده

version of a paper published in Clinical and experimental immunology. This paper has been peer-reviewed but does not include the final publisher proof-corrections or journal pagination. "Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease" Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed celiac disease Running title: Tissue transglutaminase autoantibodies and peripheral blood lymphocytes Summary Tissue transglutaminase (tTG) autoantibodies decline after gluten-free diet in patients with celiac disease. We tested the hypothesis that gluten-free diet induced change in tTG autoantibody levels affects subsets of peripheral blood lymphocytes. Peripheral blood was obtained from 20 children with biopsy-proven active celiac disease. Gluten-free diet was initiated and the children examined again after three and six months. tTG autoantibodies were measured in radioligand binding assays and lymphocyte subsets by flow cytometry. IgA-tTG levels at diagnosis, 2204 U/mL (median, range 113-24990), were reduced over six months to 76 U/mL (median, range 1-1261) (p<0.001). At six months, 12/20 (60%) children had reduced their IgA-tTG levels to <100 U/mL and these children showed a decrease in B cells (mean change-3.8%, p=0.014), CD4

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تاریخ انتشار 2005